LC-MS in Drug Bioanalysis

            High performance liquid chromatography - mass spectrometry (LC-MS) combines the separation power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. Therefore, LC-MS becomes the method of choice for drug bioanalysis in therapeutic drug monitoring, tox...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Xu, Q. Alan (Editor ), Madden, Timothy L. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer US : Imprint: Springer, 2012.
Edición:1st ed. 2012.
Temas:
Mass spectroscopy.
Analytical chemistry.
Pharmacology.
Separation (Technology).
Mass Spectrometry.
Analytical Chemistry.
Separation Science.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Internal standards for quantitative LC-MS bioanalysis
  • Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS
  • Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry
  • Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry
  • Pitfalls of LC-MS/MS in the clinical laboratory
  • Therapeutic drug monitoring to support clinical pharmacogenomics
  • Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices
  • The analysis of antipsychotic drugs in human biosamples by LC-MS
  • Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective
  • Applications of mass spectrometry in analyses of steroid hormones
  • Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications
  • Analysis of illicit drugs in human biological samples by LC-MSn
  • Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs
  • A planar integrated micro mass spectrometer.

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