Advances in Rapid Sex-Steroid Action New Challenges and New Chances in Breast and Prostate Cancers /

Rapid actions of sex steroids play a critical role in mediating the biological outcome of target tissues. This book reviews the importance of these non-genomic effects in initiation and progression of breast and prostate cancers. Particular emphasis is placed on discussing how rapid steroid actions...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Castoria, Gabriella (Editor ), Migliaccio, Antimo (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2012.
Edición:1st ed. 2012.
Temas:
Cancer.
Endocrinology.
Medicine-Research.
Biology-Research.
Cancer Biology.
Biomedical Research.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Non genomic action of steroid hormones: more questions than answers
  • Part I: Breast Cancer
  • Progesterone signaling to chromatin in breast cancer cells. two initial cycles of remodeling
  • Cooperative interactions between c-Src, estrogen receptors, and receptor tyrosine kinases in breast cancer
  • Cross talk between ERa and Src signaling and its relevance to ER status and hormone responsiveness
  • Post-translational modifications of ER alpha in rapid estrogens' action
  • Sex-steroid rapid action and its role in invasiveness and metastasis of breast cancer
  • Unraveling the role of GPER in breast cancer
  • Nongenomic actions of estrogens and xenoestrogens affecting  endocrine cancer cells
  • Part II: Prostate Cancer
  • Androgen receptor pathway in prostate cancer: old target and new drugs
  • Differential functions of stromal and epithelial androgen receptor in prostate cancer before and after castration resistant stage
  • Role of androgens and androgen receptor in prostate cancer: genomic and non-genomic actions
  • Mechanisms of signal transduction in prostate cancer: the role of PI3-kinase pathway in androgen action
  • The IGF-1 axis in prostate cancer: the role of rapid steroid actions
  • Part III: New tools for steroid receptor analysis and regulatory networks
  • Quantitative visualization of sex steroid receptor functions: AR and ERa
  • Micropatterned surfaces as tools for the study of rapid non-genomic actions of steroid receptors. Index.

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