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Caveolins and Caveolae Roles in Signaling and Disease Mechanisms /
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like cl...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
2012.
|
| Edición: | 1st ed. 2012. |
| Colección: | Advances in Experimental Medicine and Biology,
729 |
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
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| 024 | 7 | |a 10.1007/978-1-4614-1222-9 |2 doi | |
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| 245 | 1 | 0 | |a Caveolins and Caveolae |h [electronic resource] : |b Roles in Signaling and Disease Mechanisms / |c edited by Jean-François Jasmin, Philippe Frank, Michael P. Lisanti. |
| 250 | |a 1st ed. 2012. | ||
| 264 | 1 | |a New York, NY : |b Springer New York : |b Imprint: Springer, |c 2012. | |
| 300 | |a XX, 184 p. 27 illus., 1 illus. in color. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
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| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Advances in Experimental Medicine and Biology, |x 2214-8019 ; |v 729 | |
| 505 | 0 | |a Lipid Rafts, Caveolae and GPI‑Linked Proteins -- Caveolae and the Regulation of Endocytosis -- Caveolin‑1: Role in Cell Signaling -- Regulation of eNOS in Caveolae -- Recent Developments in the Interactions Between Caveolin and Pathogens -- Caveolin‑1 and Breast Cancer: A New Clinical Perspective -- Caveolin‑1 and Prostate Cancer Progression -- Caveolins and Caveolae, Roles in Insulin Signalling and Diabetes -- Atherosclerosis, Caveolae and Caveolin‑1 -- Caveolins and Heart Diseases -- Caveolins and Lung Function. | |
| 520 | |a Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm. | ||
| 650 | 0 | |a Medicine-Research. | |
| 650 | 0 | |a Biology-Research. | |
| 650 | 1 | 4 | |a Biomedical Research. |
| 700 | 1 | |a Jasmin, Jean-François. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Frank, Philippe. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Lisanti, Michael P. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9781461412212 |
| 776 | 0 | 8 | |i Printed edition: |z 9781461412236 |
| 830 | 0 | |a Advances in Experimental Medicine and Biology, |x 2214-8019 ; |v 729 | |
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| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||