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DNA Topoisomerases and Cancer
DNA topoisomerases are present in all living organisms and are essential to maintaining the helical structure of DNA. They are highly relevant for cancer because a number of anti-cancer drugs selectively target two of the human enzymes, DNA topoisomerases I and II. Those drugs convert topoisomerases...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer New York : Imprint: Humana,
2012.
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| Edición: | 1st ed. 2012. |
| Colección: | Cancer Drug Discovery and Development,
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| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Introduction and Historical Perspective
- Human DNA topoisomerase I: Structure, Enzymology and Biology
- Mitochondrial topoisomerases
- Structure and mechanism of eukaryotic type IIA topoisomerases
- Essential functions of topoisomerase III in the nucleus and mitochondria
- DNA topoisomerase I and illegitimate recombination
- Topoisomerase-induced DNA damage
- Topoisomerases and carcinogenesis: Topo III and BLM
- Topoisomerase inhibitors: a paradigm for interfacial inhibitors
- Topoisomerase I inhibitors: chemical biology
- Topoisomerase II inhibitors: chemical biology
- Topoisomerase I inhibitors: current use and prospects
- Topoisomerase II inhibitors: current use and prospects
- Transcription stress by camptothecin: mechanism and implication for the drug antitumor activity
- Mechanism regulating cellular responses to DNA topoisomerase I-targeted agents
- Tyrosyl-DNA-phosphodiesterase
- Ubiquitin and ubiquitin-like proteins in repair of topoisomerase-mediated DNA damage
- Repair of topoisomerase II-mediated DNA damage: fixing DNA damage arising from a protein covalently trapped on DNA
- Topoisomerases and Apoptosis
- Index.