Narcolepsy Pathophysiology, Diagnosis, and Treatment /

The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sle...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Baumann, Christian R. (Editor ), Bassetti, Claudio L. (Editor ), Scammell, Thomas E. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2011.
Edición:1st ed. 2011.
Temas:
Neurology .
Psychiatry.
Neurosciences.
Psychology.
Internal medicine.
Neurology.
Neuroscience.
Behavioral Sciences and Psychology.
Internal Medicine.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Etiology and genetics of human narcolepsy
  • Narcolepsy: autoimmunity or secondary to infection?
  • Is narcolepsy a neurodegenerative disorder?
  • The roles of hypocretin/orexin in narcolepsy, Parkinson's disease, and normal behaviour
  • Histamine in narcolepsy and excessive daytime sleepiness
  • Dopaminergic substrates underlying hypersomnia, sleepiness, and REM sleep expression
  • The serotoninergic system in sleep and narcolepsy
  • Sleep homeostasis, adenosine, caffeine, and narcolepsy
  • Prostaglandin D2: an endogenous somnogen
  • The neurobiology of sleep-wake systems: an overview
  • The hypocretins/orexins: master regulators of arousal and hyperarousal
  • Optogenetic probing of hypocretin/orexin regulation of wakefulness
  • Hypocretin/orexin receptor functions in mesopontine systems regulating sleep, arousal and cataplexy
  • Afferent control of the hypocretin/orexin neurons
  • The neural basis of sleepiness in narcoleptic mice
  • Mathematical models of narcolepsy
  • The hypothalamus and its functions
  • The prehistory of orexin/hypocretin and melanin-concentrating hormone neurons of the lateral hypothalamus
  • Metabolic influence on the hypocretin/orexin neurons
  • Endocrine abnormalities in narcolepsy
  • Appetite and obesity
  • Effects of orexin/hypocretin on ventral tegmental area dopamine neurons: an emerging role in addiction
  • Orexin/hypocretin, drug addiction, and narcolepsy
  • Emotional processing in narcolepsy
  • Depression in narcolepsy
  • The clinical features of cataplexy
  • Parasomnias in narcolepsy with cataplexy
  • The motor system and narcolepsy: Periodic leg movements and restless leg syndrome
  • Spectrum of narcolepsy
  • Secondary narcolepsy
  • Posttraumatic narcolepsy
  • The hypocretin/orexin system and sleepiness in Parkinson's disease
  • Idiopathic hypersomnia
  • Current diagnostic criteria of adult narcolepsy
  • The arguments for standardized diagnostic procedures
  • Fitness to drive in narcolepsy
  • Treatment of narcolepsy
  • Treatment of narcolepsy in the child.

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