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Targeting the Wnt Pathway in Cancer
The Wnt pathway is an evolutionarily conserved signaling network that is critical for mammalian development and adult tissue maintenance, and, importantly, hyperactivated in most human cancers. Almost two decades of study has confirmed that Wnt signaling is necessary and sufficient for cancer pathog...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
2011.
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| Edición: | 1st ed. 2011. |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- An Introduction to Wnt Signaling.- Regulation of Wnt Secretion and Distribution
- Wnt Signaling in Stem Cells
- Crosstalk of the Wnt Signaling Pathway
- Dysregulation of the WNT Pathway in Solid Tumors.- WNT/b-catenin Signaling in Leukemia
- Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
- Targeting Wnt Signalling in Cancer
- Inhibiting the Wnt Signaling Pathway with Small Molecules.- Targeting of Wnt Signaling Inside the Nucleus.-.