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BetaSys Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells /
The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological adva...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , , , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
2011.
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| Edición: | 1st ed. 2011. |
| Colección: | Systems Biology,
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| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Preface
- Systems biology of β-cells - revisited
- Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells - a background for a focused systems analysis approach
- Mitochondria and metabolic signals in β-cells
- β-cell ontogenesis and the insulin production apparatus
- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic β-cells
- The mathematical microscope making the inaccessible accessible
- Magnetic resonance imaging of pancreatic β-cells
- Mapping the β-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches
- In vivo applications of inorganic nanoparticles
- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts
- Bioimpedance spectroscopy
- DNA variations, impaired insulin secretion and type-2 diabetes
- Genetically programmed defects in β-cell function
- Proteomic analysis of the pancreatic islet β-cell secretory granule: current understanding and future opportunities
- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes
- Present state of islet transplantation for type-1 diabetes patients
- Predictive protein networks and identification of drugable targets in the β-cell
- Nanotoxicity
- From silicon cell to silicon human
- Probing cellular dynamics with mesoscopic simulations
- What drives calcium oscillations in β-cells? new tasks for cyclic analysis
- Whole-body and cellular models of glucose-stimulated insulin secretion
- Geometric and electromagnetic aspects of fusion pore making
- Index.