Cargando…

Inflammation and Retinal Disease: Complement Biology and Pathology

Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical cand...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Lambris, John D. (Editor ), Adamis, Anthony P. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2010.
Edición:1st ed. 2010.
Colección:Advances in Experimental Medicine and Biology, 703
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • The Case for Complement and Inflammation in AMD: Open Questions
  • The Role of Complement in AMD
  • Multiple Interactions of Complement Factor H with Its Ligands in Solution: A Progress Report
  • Genetic Control of Complement Activation in Humans and Age Related Macular Degeneration
  • Bisretinoids of RPE Lipofuscin: Trigger for Complement Activation in Age-Related Macular Degeneration
  • The Role of the Classical Complement Cascade in Synapse Loss During Development and Glaucoma
  • A Role for Complement in Glaucoma?
  • The ATP-Binding Cassette Transporter ABCA4: Structural and Functional Properties and Role in Retinal Disease
  • Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration
  • A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration
  • Complement Depletion with Humanized Cobra Venom Factor in a Mouse Model of Age-Related Macular Degeneration.