Cell Cycle Deregulation in Cancer

Modern studies of regulation of the cell division cycle were pioneered by Leland Hartwell, Paul Nurse, and Tim Hunt in yeast and marine invertebrates. This work identified proteins termed cyclins that fluxuate in abundance during progression through the cycle and partner with Cyclin dependent kinase...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Enders, Greg H. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2010.
Edición:1st ed. 2010.
Colección:Current Cancer Research,
Temas:
Cancer.
Pharmacology.
Cancer Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Starting the Cell Division Cycle
  • Escape from Cellular Quiescence
  • Interplay Between Cyclin-Dependent Kinases and E2F-Dependent Transcription
  • Regulation of Pre-RC Assembly: A Complex Symphony Orchestrated by CDKs
  • Proliferation Under Duress
  • Mitotic Checkpoint and Chromosome Instability in Cancer
  • Mitotic Catastrophe
  • p53, ARF, and the Control of Autophagy
  • Long-Term Proliferation
  • Regulation of Self-Renewing Divisions in Normal and Leukaemia Stem Cells
  • Maintenance of Telomeres in Cancer
  • The Senescence Secretome and Its Impact on Tumor Suppression and Cancer
  • Applications in Preventing and Treating Cancer
  • Cell Cycle Deregulation in Pre-neoplasia: Case Study of Barrett's Oesophagus
  • Targeting Cyclin-Dependent Kinases for Cancer Therapy.

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