Enzyme- and Transporter-Based Drug-Drug Interactions Progress and Future Challenges /

This volume is authored by esteemed experts in the field, and provides state-of-the art knowledge related to enzyme- and transporter-based DDIs that impact the absorption and disposition of drugs. It examines the types of DDIs, methodological approaches to evaluate and view DDIs mechanistically, bio...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Pang, K. Sandy (Editor ), Rodrigues, A. David (Editor ), Peter, Raimund M. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2010.
Edición:1st ed. 2010.
Temas:
Pharmacology.
Analytical chemistry.
Medicinal chemistry.
Analytical Chemistry.
Medicinal Chemistry.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Determinants of Drug ADME
  • Enzymatic Basis of Phase I and Phase II Drug Metabolism
  • Transporters: Importance in Drug Absorption, Distribution, and Removal
  • ADME Pharmacogenetics and Its Impact on Drug-Drug Interactions
  • Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters
  • Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and Total Body Clearances
  • Methods For The Study Of Drug-Drug Interactions
  • In Silico Approaches to Predict DDIs
  • In Vitro Techniques to Study Drug-Drug Interactions of Drug Metabolism: Cytochrome P450
  • The In Vitro Characterization of Inhibitory Drug-Drug Interactions Involving UDP-Glucuronosyltransferase
  • In Vitro Techniques to Study Transporter-Based DDI
  • In Vitro Techniques to Study Drug-Drug Interactions Involving Transport: Caco-2 Model for Study of P-Glycoprotein and Other Transporters
  • Use of In Vivo Animal Models to Assess Drug-Drug Interactions
  • Extrapolation of In Vitro Metabolic and P-Glycoprotein-Mediated Transport Data to In Vivo by Modeling and Simulations
  • Translation of In Vitro Metabolic Data to Predict In Vivo Drug-Drug Interactions: IVIVE and Modeling and Simulations
  • Absorption Models to Examine Bioavailability and Drug-Drug Interactions in Humans
  • Management of Drug Interactions of New Drugs in Multicenter Trials Using the Metabolism and Transport Drug Interaction Database©
  • Web-Based Database as a Tool to Examine Drug-Drug Interactions Involving Transporters
  • Impact Of Drug-Drug Interactions
  • Drug Disposition and Drug-Drug Interactions: Importance of First-Pass Metabolism in Gut and Liver
  • Transporter-Based Drug-Drug Interactions and Their Effect on Distribution Volumes
  • Inactivation of Human Cytochrome P450 Enzymes and Drug-Drug Interactions
  • Allosteric Enzyme- and Transporter-Based Interactions
  • The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug-Drug Interactions in Humans
  • Herbal Supplement-Based Interactions
  • Anticipating and Minimizing Drug Interactions in a Drug Discovery and Development Setting: An Industrial Perspective
  • Clinical Studies of Drug-Drug Interactions: Design and Interpretation
  • Toxicological Consequences of Drug-Drug Interactions
  • Regulatory Aspects And Future Developments Involving DDI
  • Complex Drug Interactions: Significance and Evaluation
  • Drug-Drug Interactions: Communicating Post-market Drug Safety Information in the USA
  • Drug-Drug Interactions: What Have We Learned and Where Are We Going?.

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