Cancer Genome and Tumor Microenvironment

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late '80s-mid '90s, neoplastic growth was described largely as a net imbalanc...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Thomas-Tikhonenko, Andrei (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2010.
Edición:1st ed. 2010.
Colección:Cancer Genetics,
Temas:
Cancer.
Oncology.
Cancer Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Opening Remarks
  • Hardwiring Tumor Progression
  • Breaking Away: Epithelial-Mesenchymal Transition
  • PI3K/AKT Pathway and the Epithelial-Mesenchymal Transition
  • Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells
  • Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment
  • Merlin/NF2 Tumor Suppressor and Ezrin-Radixin-Moesin (ERM) Proteins in Cancer Development and Progression
  • Coming up for Air: Hypoxia and Angiogenesis
  • von Hippel-Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularization
  • RAS Oncogenes and Tumor-Vascular Interface
  • Myc and Control of Tumor Neovascularization
  • p53 and Angiogenesis
  • Ink4a Locus: Beyond Cell Cycle
  • Gaining New Ground: Metastasis and Stromal Cell Interactions
  • Nm23 as a Metastasis Inhibitor
  • HGF/c-MET Signaling in Advanced Cancers
  • Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasis
  • Stromal Cells and Tumor Milieu: PDGF et al.
  • TGF-? Signaling Alterations in Neoplastic and Stromal Cells
  • Getting Attention: Immune Recognition and Inflammation
  • Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers
  • Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis
  • Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironment
  • Putting It All Together
  • Melanoma: Mutations in Multiple Pathways at the Tumor-Stroma Interface
  • Cooperation and Cancer.

Ejemplares similares