Cargando…

Oral Delivery of Macromolecular Drugs Barriers, Strategies and Future Trends /

Due to a rapid development in biotechnology more and more macromolecular drugs such as therapeutic peptides, oligosaccharides and nucleic acids are entering the pharmaceutical arena representing unprecedented challenges from the drug delivery point of view. One of the likely greatest challenges is t...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Bernkop-Schnürch, Andreas (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2009.
Edición:1st ed. 2009.
Temas:
Acceso en línea:Texto Completo

MARC

LEADER 00000nam a22000005i 4500
001 978-1-4419-0200-9
003 DE-He213
005 20220114210515.0
007 cr nn 008mamaa
008 100715s2009 xxu| s |||| 0|eng d
020 |a 9781441902009  |9 978-1-4419-0200-9 
024 7 |a 10.1007/978-1-4419-0200-9  |2 doi 
050 4 |a RM300-666 
072 7 |a MMG  |2 bicssc 
072 7 |a MED071000  |2 bisacsh 
072 7 |a MKG  |2 thema 
082 0 4 |a 615  |2 23 
245 1 0 |a Oral Delivery of Macromolecular Drugs  |h [electronic resource] :  |b Barriers, Strategies and Future Trends /  |c edited by Andreas Bernkop-Schnürch. 
250 |a 1st ed. 2009. 
264 1 |a New York, NY :  |b Springer New York :  |b Imprint: Springer,  |c 2009. 
300 |a XIII, 242 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a Enzymatic Barriers -- Gastrointestinal Mucus Gel Barrier -- The Absorption Barrier -- Strategies to Overcome the Enzymatic Barrier -- Low Molecular Mass Permeation Enhancers in Oral Delivery of Macromolecular Drugs -- Polymeric Permeation Enhancers -- Strategies to Overcome Efflux Pumps -- Multifunctional Polymeric Excipients in Oral Macromolecular Drug Delivery -- Nano- and Microparticles in Oral Delivery of Macromolecular Drugs -- Liposome-Based Mucoadhesive Formulations for Oral Delivery of Macromolecules -- Strategies in Oral Immunization -- Oral Delivery of Nucleic Acid Drugs. 
520 |a Due to a rapid development in biotechnology more and more macromolecular drugs such as therapeutic peptides, oligosaccharides and nucleic acids are entering the pharmaceutical arena representing unprecedented challenges from the drug delivery point of view. One of the likely greatest challenges is their oral administration presenting a series of attractive advantages. Oral Delivery of Macromolecular Drugs addresses the most critical issues for a successful oral delivery of macromolecular drugs by a detailed characterisation of the 'enemy's strength' which is mainly based on the enzymatic barrier, the mucus gel barrier and the absorption barrier. Each of these barriers is described in detail in separate chapters by leading scientists in the field. The higher the knowledge about these barriers, the more potent oral macromolecular delivery systems can be generated. In the second part of this volume an overview on the likely most promising strategies to overcome these barriers is provided. Each of these strategies is described in detail in chapters being authored by worldwide academic and industrial experts. These strategies include the use of auxiliary agents such as polymeric and low molecular mass permeation enhancers, efflux pump inhibitors and enzyme inhibitors. Furthermore, these strategies are based on delivery systems such as liposomal formulations and micro- and nanoparticles. Oral Delivery of Macromolecular Drugs provides also an overview on special topics in oral macromolecular drug delivery such as oral immunization and gene delivery. Each of these chapters benefits from the results of various in vivo studies demonstrating the potential of discussed delivery systems. On the one hand macromolecular drugs can be produced more and more effectively making also low oral bioavailabilities in the range of 0.5 - 5% commercially interesting. On the other hand, oral macromolecular drug formulations are becoming more and more efficient. Taking these developments into consideration, the number of oral macromolecular delivery systems entering the market will increase considerably over the years. 'Invasive-to-oral-conversions' promise great rewards for those investing in this market. Oral Delivery of Macromolecular Drugs should encourage and motivate scientists in academia and industry to move in or intensively their activities in this challenging research field of great future. About the Editor Andreas Bernkop-Schnürch is the Dean of the Faculty of Chemistry and Pharmacy and Professor of Pharmaceutical Technology at the University of Innsbruck, Austria. His main interests focus on non-invasive drug delivery systems, multifunctional polymers such as thiomers, mucoadhesion and permeation enhancement. He is author of more than 200 original research and review articles and received the Research-Award of the City of Vienna (Vienna), EURAND-Award (Boston), Best of Biotech Award (Vienna), MBPW-Award (Munich), PHÖNIX Award (Mannheim), Houska-Award (Vienna) and Austrian-Nanoaward (Vienna). In addition, Andreas Bernkop-Schnürch is founder and owner of the following companies: ThioMatrix GmbH, Dr. K. Schnürch KG and Green River Polymers GmbH. 
650 0 |a Pharmacology. 
650 0 |a Biochemistry. 
650 0 |a Cytology. 
650 1 4 |a Pharmacology. 
650 2 4 |a Biochemistry. 
650 2 4 |a Cell Biology. 
700 1 |a Bernkop-Schnürch, Andreas.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9781441902016 
776 0 8 |i Printed edition:  |z 9781441901996 
776 0 8 |i Printed edition:  |z 9781489982827 
856 4 0 |u https://doi.uam.elogim.com/10.1007/978-1-4419-0200-9  |z Texto Completo 
912 |a ZDB-2-SBL 
912 |a ZDB-2-SXB 
950 |a Biomedical and Life Sciences (SpringerNature-11642) 
950 |a Biomedical and Life Sciences (R0) (SpringerNature-43708)