Advances in Bioactivation Research

I have always been interested in chemistry and biology. My undergraduate, graduate, and postdoctoral trainings in pharmacy, medicinal chemistry and pharmacology, respectively, have strengthened this interest and led me to realize that significant advances in medicine have frequently been realized be...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Elfarra, Adnan (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2008.
Edición:1st ed. 2008.
Colección:Biotechnology: Pharmaceutical Aspects ; IX
Temas:
Pharmacology.
Immunology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • General Concepts and Basic Mechanisms
  • Metabolic Concerns in Drug Design
  • Role of Bioactivation in Idiosyncratic Drug Toxicity: Structure#x2013;Toxicity Relationships
  • Michael Addition#x2013;Elimination Reactions: Roles in Toxicity and Potential New Therapeutic Applications
  • Induction of Drug-Metabolizing Enzymes: Contrasting Roles in Detoxification and Bioactivation of Drugs and Xenobiotics
  • Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes
  • CYP2E1 #x2013; Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury
  • One- and Two-Electron-Mediated Reduction of Quinones: Enzymology and Toxicological Implications
  • Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates
  • Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes
  • Tissue-Specific Features and Risk Assessment Applications
  • Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death
  • Hepatic Bioactivation and Drug-Induced Liver Injury
  • Role of Cysteine S-Conjugate #x03B2;-Lyases in the Bioactivation of Renal Toxicants
  • Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs
  • Generation of Reactive Metabolites and Associated DNA Adducts from Benzene, Butadiene, and PAH in Bone Marrow. Their Effects on Hematopoiesis and Impact on Human Health
  • Butadiene-Mediated Mutagenesis and Carcinogenesis
  • Pharmacogenetics of Drug Bioactivation Pathways
  • Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons.

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