Drug Addiction From Basic Research to Therapy /

Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, genetic and behavioral pathways underlying drug addiction. Focusing on fundamental neurophysiological processes that overlap between drug addiction and other CNS disorders, this volume cov...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Rapaka, Rao S. (Editor ), Sadée, Wolfgang (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2008.
Edición:1st ed. 2008.
Temas:
Pharmacology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • General Topics
  • DARPP-32 Mediates the Actions of Multiple Drugs of Abuse
  • Drug Discovery From Natural Sources
  • Computational Methods in Drug Design: Modeling G Protein-Coupled Receptor Monomers, Dimers, and Oligomers
  • Symbiotic Relationship of Pharmacogenetics and Drugs of Abuse
  • Monoclonal Antibody Form and Function: Manufacturing the Right Antibodies for Treating Drug Abuse
  • Cocaine- and Amphetamine-Regulated Transcript Peptides Play a Role in Drug Abuse and Are Potential Therapeutic Targets
  • RNAi-Directed Inhibition of DC-SIGN by Dendritic Cells: Prospects for HIV-1 Therapy
  • Viewing Chemokines as a Third Major System of Communication in the Brain
  • Targeting the PDZ Domains of Molecular Scaffolds of Transmembrane Ion Channels
  • Neuronal Nicotinic Acetylcholine Receptor Expression and Function on Nonneuronal Cells
  • Transporters & Stimulants & Hallucinogens
  • Role of Monoamine Transporters in Mediating Psychostimulant Effects
  • Development of the Dopamine Transporter Selective RTI-336 as a Pharmacotherapy for Cocaine Abuse
  • Serotonin Transporters: Implications for Antidepressant Drug Development
  • Recent Advances for the Treatment of Cocaine Abuse: Central Nervous System Immunopharmacotherapy
  • ? Opioids as Potential Treatments for Stimulant Dependence
  • Regulation of Monoamine Transporters: Influence of Psychostimulants and Therapeutic Antidepressants
  • Hallucinogen Actions on 5-HT Receptors Reveal Distinct Mechanisms of Activation and Signaling by G Protein-Coupled Receptors
  • Recognition of Psychostimulants, Antidepressants, and Other Inhibitors of Synaptic Neurotransmitter Uptake by the Plasma Membrane Monoamine Transporters
  • Dual Dopamine/Serotonin Releasers as Potential Medications for Stimulant and Alcohol Addictions
  • Receptors of Mammalian Trace Amines
  • Drug Design: Nicotine, Opioids and Related Ligands
  • The Role of Crystallography in Drug Design
  • Opioid Peptide-Derived Analgesics
  • Opioid Ligands with Mixed ?/? Opioid Receptor Interactions: An Emerging Approach to Novel Analgesics
  • Small-Molecule Agonists and Antagonists of the Opioid Receptor-Like Receptor (ORL1, NOP): Ligand-Based Analysis of Structural Factors Influencing Intrinsic Activity at NOP
  • Kappa Opioid Antagonists: Past Successes and Future Prospects
  • In Vitro and Direct In Vivo Testing of Mixture-Based Combinatorial Libraries for the Identification of Highly Active and Specific Opiate Ligands
  • Current Status of Immunologic Approaches to Treating Tobacco Dependence: Vaccines and Nicotine-Specific Antibodies
  • New Paradigms and Tools in Drug Design for Pain and Addiction
  • Opioids: General
  • Neuropeptide-Processing Enzymes: Applications for Drug Discovery
  • CNS Drug Delivery: Opioid Peptides and the Blood-Brain Barrier
  • Cell-Permeable, Mitochondrial-Targeted, Peptide Antioxidants
  • Targeting Opioid Receptor Heterodimers: Strategies for Screening and Drug Development
  • Homology Modeling of Opioid Receptor-Ligand Complexes Using Experimental Constraints
  • Molecular Recognition of Opioid Receptor Ligands
  • Role of Morphine's Metabolites in Analgesia: Concepts and Controversies
  • Mu Opioid Receptor Regulation and Opiate Responsiveness
  • Agmatine: Biological Role and Therapeutic Potentials in Morphine Analgesia and Dependence
  • Cannabinoid
  • The Therapeutic Potential of Drugs that Target Cannabinoid Receptors or Modulate the Tissue Levels or Actions of Endocannabinoids
  • Further Advances in the Synthesis of Endocannabinoid-Related Ligands
  • Ajulemic Acid (IP-751): Synthesis, Proof of Principle, Toxicity Studies, and Clinical Trials
  • Conformational Characteristics of the Interaction of SR141716A with the CB1 Cannabinoid Receptor as Determined Through the Use of Conformationally Constrained Analogs
  • Activation of G-Proteins in Brain by Endogenous and Exogenous Cannabinoids
  • 2-Arachidonoylglycerol (2-AG) Membrane Transport: History and Outlook
  • Endocannabinoid Mechanisms of Pain Modulation.

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