Drug Absorption Studies In Situ, In Vitro and In Silico Models /

In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Ehrhardt, Carsten (Editor ), Kim, Kwang-Jin (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer US : Imprint: Springer, 2008.
Edición:1st ed. 2008.
Colección:Biotechnology: Pharmaceutical Aspects ; VII
Temas:
Pharmacology.
Biotechnology.
Cytology.
Medical sciences.
Cell Biology.
Health Sciences.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Perfused Organ Level/In Situ Techniques
  • Models for Skin Absorption and Skin Toxicity Testing
  • Models of the Small Intestine
  • Drug Absorption from the Colon In Situ
  • In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa
  • In Situ and Ex Vivo Nasal Models for Preclinical Drug Development Studies
  • The Isolated Perfused Lung for Drug Absorption Studies
  • Cellular Level-In Vitro Models of Epithelial and Endothelial Barriers
  • In Vitro Models for Investigations of Buccal Drug Permeation and Metabolism
  • In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolism
  • In Vitro Cellular Models for Nasal Drug Absorption Studies
  • In Vitro Models of the Tracheo-Bronchial Epithelium
  • In Vitro Models of the Alveolar Epithelial Barrier
  • Cell Culture Models of the Corneal Epithelium and Reconstructed Cornea Equivalents for In Vitro Drug Absorption Studies
  • The Conjunctival Barrier in Ocular Drug Delivery
  • Inner Blood-Retinal Barrier: Transport Biology and Methodology
  • Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epithelia
  • In Vitro Models and Multidrug Resistance Mechanisms of the Placental Barrier
  • In Vitro Models to Study Blood-Brain Barrier Function
  • High-Throughput Screening Using Caco-2 Cell and PAMPA Systems
  • Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations
  • Bioinformatics-In Silico Tools to Predict Drug Absorption
  • Modeling Transdermal Absorption
  • Physiologically Based in Silico Models for the Prediction of Oral Drug Absorption
  • In Silico Modeling for Blood-Brain Barrier Permeability Predictions
  • Molecular/Sub-Cellular Level-Mechanistic Tools
  • Impact of Drug Transport Proteins
  • Cloning and Functional Heterologous Expression of Transporters
  • The Pharmacology of Caveolae
  • Immortalization Strategies for Epithelial Cells in Primary Culture
  • Binding-Uptake Studies and Cellular Targeting
  • Regulatory Considerations
  • Drug Permeability Studies in Regulatory Biowaiver Applications.

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