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The p53 Tumor Suppressor Pathway and Cancer
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a tran...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer US : Imprint: Springer,
2005.
|
| Edición: | 1st ed. 2005. |
| Colección: | Protein Reviews ;
2 |
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
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| 001 | 978-0-387-30127-3 | ||
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| 005 | 20220116011802.0 | ||
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| 020 | |a 9780387301273 |9 978-0-387-30127-3 | ||
| 024 | 7 | |a 10.1007/0-387-30127-5 |2 doi | |
| 050 | 4 | |a RC261-271 | |
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| 245 | 1 | 4 | |a The p53 Tumor Suppressor Pathway and Cancer |h [electronic resource] / |c edited by Gerard P. Zambetti. |
| 250 | |a 1st ed. 2005. | ||
| 264 | 1 | |a New York, NY : |b Springer US : |b Imprint: Springer, |c 2005. | |
| 300 | |a X, 246 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Protein Reviews ; |v 2 | |
| 505 | 0 | |a The p53 Network -- The Three-Dimensional Structure of p53 -- Transcriptional Activation by p53: Mechanisms and Targeted Genes -- Transcriptional Repression by the p53 Tumor Suppressor Protein -- Posttranslational Modifications of p53: Upstream Signaling Pathways -- p53 in Human Cancer - Somatic and Inherited Mutations and Mutation-independent Mechanisms -- MDM2 and MDMX Regulators of p53 Activity -- p53 Family Members: p63 and p73 -- The Oncogenic Activity of p53 Mutants -- Therapeutic Strategies Based on Pharmacological Modulation of p53 Pathway. | |
| 520 | |a The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world. | ||
| 650 | 0 | |a Cancer. | |
| 650 | 0 | |a Oncology. | |
| 650 | 0 | |a Biochemistry. | |
| 650 | 0 | |a Cytology. | |
| 650 | 0 | |a Clinical biochemistry. | |
| 650 | 0 | |a Medical genetics. | |
| 650 | 1 | 4 | |a Cancer Biology. |
| 650 | 2 | 4 | |a Oncology. |
| 650 | 2 | 4 | |a Biochemistry. |
| 650 | 2 | 4 | |a Cell Biology. |
| 650 | 2 | 4 | |a Medical Biochemistry. |
| 650 | 2 | 4 | |a Medical Genetics. |
| 700 | 1 | |a Zambetti, Gerard P. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9780387504322 |
| 776 | 0 | 8 | |i Printed edition: |z 9780387241357 |
| 776 | 0 | 8 | |i Printed edition: |z 9781489998798 |
| 830 | 0 | |a Protein Reviews ; |v 2 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/0-387-30127-5 |z Texto Completo |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||