The Proteasome in Neurodegeneration

"Protein degradation, especially via the ubiquitin-proteosome system, has emerged as a critical molecular component to mechanisms of cell death in a variety of prominent neurodegenerative diseases. Thus, the editors of this book should be praised for the comprehensiveness and timeliness of thei...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Stefanis, Leonidas (Editor ), Keller, J. N. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer US : Imprint: Springer, 2006.
Edición:1st ed. 2006.
Temas:
Neurosciences.
Cytology.
Neuroscience.
Cell Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Basic Aspects of Protein Degradation Through the Ubiquitin Proteasome System (UPS)
  • Yeast Proteasome Structure and Biogenesis
  • Ubiquitin-Proteasome System in the Central Nervous System
  • Protein Aggregation, Inclusion Formation and Ups Function
  • Protein Aggregation and the UPS: A Two-Way Street
  • The Impact of Inclusion Formation on Cell Survival
  • Inclusion Formation and Disolution Following Proteasomal Inhibition in Neuronal Cells
  • Oxidative Stress and Ups Function
  • The Proteasome: Source and a Target of Oxidative Stress?
  • Inflammation as a Mediator of Oxidative Stress and UPS Dysfunction
  • Proteasome and Neuronal Cell Death and Survival
  • Role of the Ubiquitin Proteasome System During Neuronal Cell Death
  • Pathways of Neuronal Cell Death Induced by Proteasomal Inhibition
  • Models of Dysfunction of the UPS and the Proteasome
  • Pharmacological and Molecular Models of Proteasomal Dysfunction
  • The Gad Mouse: A Window Into UPS-Related Neurodegeneration and the Function of the Function of the Deubiquitinating Enzyme Uch-L1
  • The UPS in Neurodegenerative Diseases and Aging
  • Parkinson's Disease and Related Disorders
  • Ubiquitination by Parkin - Implications in Parkinson's Disease
  • The Ups in Neurodegenerative Diseases and Aging Huntington's Disease
  • Frameshift Mutant Ubiquitin in Alzheimer's Disease and Other Neurodegenerative Disorders
  • Motor Neuron Disease
  • The Paradoxical Role of Proteasomes in Prion Disorders
  • Aging and the Proteasome.

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