Cargando…

Hypocretins Integrators of Physiological Signals /

The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundament...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: De Lecea, Luis (Editor ), Sutcliffe, J. Gregor (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer US : Imprint: Springer, 2005.
Edición:1st ed. 2005.
Temas:
Acceso en línea:Texto Completo

MARC

LEADER 00000nam a22000005i 4500
001 978-0-387-25446-3
003 DE-He213
005 20220116010835.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 |a 9780387254463  |9 978-0-387-25446-3 
024 7 |a 10.1007/b107412  |2 doi 
050 4 |a RC321-580 
072 7 |a PSAN  |2 bicssc 
072 7 |a MED057000  |2 bisacsh 
072 7 |a PSAN  |2 thema 
082 0 4 |a 612.8  |2 23 
245 1 0 |a Hypocretins  |h [electronic resource] :  |b Integrators of Physiological Signals /  |c edited by Luis De Lecea, J. Gregor Sutcliffe. 
250 |a 1st ed. 2005. 
264 1 |a New York, NY :  |b Springer US :  |b Imprint: Springer,  |c 2005. 
300 |a XXIV, 441 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a Discovery of the Hypocretins/Orexins and Their Receptors -- The Discovery of the Hypocretins -- Orexin and Orexin Receptors -- Animal Models in the Study of the Hypocretinergic System -- Rodent Models of Human Narcolepsy-cataplexy -- The Canine Model of Narcolepsy -- Detailed Anatomy of the Hypocretinergic System and Related Hypothalamic Circuits -- Anatomy of the Hypocretin System -- The Anatomy of Hypocretin Neurons -- Transmitter-Identified Neurons and Afferent Innervation of the Lateral Hypothalamic Area -- Physiological Consequences of Hypocretin Activation -- Physiological Characteristics of Hypocretin/Orexin Neurons -- The Ne System as a Target for Hypocretin Neurons -- Hypocretin/Orexin Actions on Mesopontine Cholinergic Systems Controling Behavioral State -- The Aminergic Systems and the Hypocretins -- Effects Of Hypocretin/Orexin on the Thalamocortical Activating System -- Pharmacology of the Hypocretins and Drug Design -- In Vivo Pharmacology of Orexin (Hypocretin) Receptors -- Intracellular Signal Pathways Utilized by the Hypocretin/Orexin Receptors -- The Hypocretins in Narcolepsy and Arousal -- The Hypocretins and Narcolepsy -- An Approach to Determining the Functions of Hypocretin (Orexin) -- Hypocretin in Neuropsychiatric Disorders -- Hypocretin/Orexin and Sleep -- Modulation of Cortical Activity and Sleep-Wake States by Hypocretin/Orexin -- The Hypocretins in Feeding and Energy Balance -- Regulation of Hypocretin by Metabolic Signals -- The Hypocretins in Addiction and Hyperarousal -- Hypocretin and Brain Reward Function -- Orexin/Hypocretin and Opioid Dependence -- Dopamine-Hypocretin/Orexin Interactions -- Hypocretin/Orexin in Stress and Arousal -- Role of Hypocretins on Peripheral Systems -- The Hypocretins/Orexins and the Hypothalamo-Pituitary-Adrenal Axis -- Orexins (Hypocretins) in the Gut -- Hypocretins in Endocrine Regulation -- The Hypocretins in Cardiovascular Regulation. 
520 |a The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with "wide awake" EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999. 
650 0 |a Neurosciences. 
650 0 |a Endocrinology. 
650 0 |a Neurology . 
650 1 4 |a Neuroscience. 
650 2 4 |a Endocrinology. 
650 2 4 |a Neurology. 
700 1 |a De Lecea, Luis.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
700 1 |a Sutcliffe, J. Gregor.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9780387505572 
776 0 8 |i Printed edition:  |z 9780387250007 
776 0 8 |i Printed edition:  |z 9781461498063 
856 4 0 |u https://doi.uam.elogim.com/10.1007/b107412  |z Texto Completo 
912 |a ZDB-2-SBL 
912 |a ZDB-2-SXB 
950 |a Biomedical and Life Sciences (SpringerNature-11642) 
950 |a Biomedical and Life Sciences (R0) (SpringerNature-43708)