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|a 9780387228259
|9 978-0-387-22825-9
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|a 10.1007/b99419
|2 doi
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|a MJD
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|a MJD
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|a 616.12
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|a Interstitial Fibrosis in Heart Failure
|h [electronic resource] /
|c edited by Francisco Villarreal.
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|a 1st ed. 2005.
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2005.
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|a XIV, 373 p. 93 illus.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
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|a online resource
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|a Developments in Cardiovascular Medicine ;
|v 253
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|a Architecture of the Normal and Remodeled Heart -- The Architecture of the Heart: Myocyte Organization and the Cardiac Extracellular Matrix -- Extracellular Matrix and Cardiac Remodeling -- Pro-Inflammatory Cytokines and Cardiac Extracellular Matrix: Regulation of Fibroblast Phenotype -- Pharmacology of G-Protein-linked Signaling in Cardiac Fibroblasts -- Diagnostic Tools for the Identification of Myocardial Fibrosis and Changes in Ventricular Mechanics -- Serum Markers of Fibrillar Collagen Metabolism in Cardiac Diseases -- Ultrasonic Characterization of the Myocardium -- The Mechanics of the Fibrosed/Remodeled Heart -- Pathophysiology of Cardiac Remodeling and Fibrosis -- Renin Angiotensin Aldosterone System and Cardiac Extracellular Matrix -- Matrix Metalloproteinases and Myocardial Remodeling -- Cardiac Mast Cells as Mediators of Ventricular Remodeling -- Matrix Metalloproteinasses in Cardiac Remodeling -- Turmoil in the Cardiac Myocyte: Acute Intracellular Activation of Matrix Metalloproteinases -- Regulation of Cardiac Extracellular Matrix Remodeling Following Myocardial Infarction. -- Experimental Models of MMP Activation: Ventricular Volume Overload -- Prospect for Therapy of the Fibrosed Heart -- Targets for Pharmacological Modulation of Cardiac Fibrosis -- Biological and Functional Effects of Chronic Mechanical Support Induced by Left Ventricular Assist Devices on Failing Human Myocardium -- Molecular Strategies for the Prevention of Cardiac Fibrosis -- Prospects for Gene Therapy for the Fibrosed Heart: Targeting Regulators of Extracellular Matrix Turnover -- Therapeutic Potential of TIMPs in Heart Failure.
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|a Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.
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|a Cardiology.
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|a Heart-Surgery.
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|a Cardiology.
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|a Cardiac Surgery.
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|a Villarreal, Francisco.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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|a SpringerLink (Online service)
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|t Springer Nature eBook
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|i Printed edition:
|z 9780387501918
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|i Printed edition:
|z 9781441919830
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|i Printed edition:
|z 9780387228242
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|a Developments in Cardiovascular Medicine ;
|v 253
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|u https://doi.uam.elogim.com/10.1007/b99419
|z Texto Completo
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|a ZDB-2-SME
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|a Medicine (SpringerNature-11650)
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|a Medicine (R0) (SpringerNature-43714)
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